The chest wall of a mouse treated with GL-ONC1 is completely mesothelioma tumor free (Top), while (Bottom) untreated mice continue to bear heavy tumor burdens. [Kelly K, et al. 2008. Human Gene Therapy]
Malignant pleural mesothelioma is a fatal disease with a median life expectancy of less than 14 months. In animal models bearing human mesothelioma tumors, GL-ONC1 was successful in treating the disease, clearing the chest wall completely.